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WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure.〔Compton DR, ''et al.'' Aminoalkylindole Analogs: Cannabimimetic Activity of a Class of Compounds Structurally Distinct from Δ9-Tetrahydrocannabinol. ''Journal of Pharmacology and Experimental Therapeutics''. 1992; 263(3):1118-1126.〕〔 〕 WIN 55,212-2 is a potent cannabinoid receptor agonist that has been found to be a potent analgesic in a rat model of neuropathic pain. It activates p42 and p44 MAP kinase via receptor-mediated signaling. At 5 µM WIN 55,212-2 inhibit ATP production in sperm in a CB1 receptor-dependent fashion.〔 〕 WIN 55,212-2, along with HU-210 and JWH-133, may prevent the inflammation caused by amyloid beta proteins involved in Alzheimer's disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through agonist action at cannabinoid receptors, which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglial activation in rat models. WIN 55,212-2 is a full agonist at the CB1 cannabinoid receptor (''K''i = 1.9 nM) and has much higher affinity than THC (''K''i = 41 nM) for this receptor.〔 〕 WIN 55,212-2 reduces voluntary wheel running in laboratory mice, but with effects that depend on both genetic background and sex. WIN 55,212-2 is illegal in the UK ==See also== * WIN 48,098 * WIN 54,461 * WIN 55,225 * WIN 56,098 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「WIN 55,212-2」の詳細全文を読む スポンサード リンク
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